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A large prospective cohort study that tracked over 1,700 patients demonstrated that patients who underwent a Roux-en-Y gastric bypass lost an excess 21% of their body mass normalized to their non-surgical matched controls at the 10 year point (corresponding to 35 kg (~77 lbs) greater weight loss)

Various processes have been hypothesized to disrupt control mechanisms that safeguard against cellular antioxidants and induce injury to hepatocytes due to oxidative stress

TGR5 Bile acids (BAs) are cholesterol-derived molecules produced in the liver and temporarily stored in the gallbladder

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